Various factors including arterial pressure, vasomotor activity, noradrenaline, potassium, angiotensin II, and sodium load influence the intrarenal secretion of renin into the bloodstream.
True renin is known to be secreted into the blood stream from the juxtaglomerular apparatus (J.G.A.) of the kidney (Hartroft Hartroft, 1957 Cook Chandra et al, 1964; Robertson et al, 1965), and many of the factors influencing the rate of this secretion have been established. A small fall in systemic mean arterial pressure (To-bian, 1960; Skinner et al, 1963 Brown et al, 1964). Conversely, sodium-loading decreases the granularity of the J. G. cells and causes a fall in the concentration of plasma renin (Hartroft Brown et al, 1964). Finally, the secretion of renin into the blood stream is thought to be influenced either by the load or concentration of sodium passing the luminal surface of the macula densa, or traversing the cells (Thurau, 1964; Vander Gross et al, 1965; Vander, 1967; Vander & Carlson, 1969).
Gan et al. (1973) conducted a review in Factors affecting intrarenal secretion of renin. Various factors including arterial pressure, vasomotor activity, noradrenaline, potassium, angiotensin II, and sodium load influence the intrarenal secretion of renin into the bloodstream.