A32-34 Gender Disparities in Anaphylactic Shock - A Retrospective Cohort Study

Abstract Anaphylactic shock is an acute, life-threatening hypersensitivity reaction leading to circulatory collapse. Gender disparities are a rising trend bringing closer attention to individualized medicine. Allergic diseases and reactions are of important focus as gender has been linked to different disease courses. Our goal was to investigate the impact gender has on clinical outcomes of patients admitted with Anaphylactic shock. Using the National Inpatient Sample Database from 2019-2022, we conducted a retrospective analysis of patients who were admitted with anaphylactic shock using international classification of diseases (ICD 10) codes. Patients were divided into two groups, based on gender. Using both univariate and multivariate analyses, we compared the odds of various in-hospital outcomes and adjusted for confounders. There were 7970 admissions for anaphylactic shock, 59 % were female and 41 % were males. The primary outcome of interest was in-hospital mortality. Secondary outcomes included length of stay (LOS), total charges (TOTCHG), acute respiratory failure (ARF), cardiac arrest (CA), mechanical ventilation (MV), and acute kidney injury (AKI). There was no difference in mortality between both genders (adjusted odds ratio (aOR): 0. 93, CI: 0. 24-3. 56, p 0. 919). Regarding secondary outcomes, there were no differences in TOTCHG (46533 vs 47513, Coe: 2706 CI: - 4547- 9959, p 0. 47), mean LOS (2. 8 days vs 3. 3 days, Coe: 0. 34 days CI: -0. 10 - 0. 77, p 0. 13), ARF (aOR: 0. 96, CI: 0. 72-1. 29, P0. 79), MV (aoR: 1. 07, CI 0. 79-1. 46, p0. 66) and less odds of AKI (aOR: 0. 32, CI: 0. 22-0. 46, p0. 00) in females compared to males. As expected, females have higher incidents of anaphylactic shock. No associations in mortality have been seen with regard to gender. There is, however, less AKI seen in female patients admitted with anaphylactic shock compared to male patients. Although gender disparities have been linked with many medical conditions, when it comes to anaphylactic shock, no association has been found. This abstract is funded by: None