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The accumulation of d -alanine, l -alanine, glycine, and d -cycloserine in Escherichia coli was found to be mediated by at least two transport systems. The systems for d -alanine and glycine are related, and are separate from that involved in the accumulation of l -alanine. d -Cycloserine appears to be primarily transported by the d -alanine-glycine system. The accumulation of d -alanine, glycine, and d -cycloserine was characterized by two line segments in the Lineweaver-Burk analysis, whereas the accumulation of l -alanine was characterized by a single line segment. d -Cycloserine was an effective inhibitor of glycine and d -alanine accumulation, and l -cycloserine was an effective inhibitor of l -alanine transport. The systems were further differentiated by effects of azide, enhancement under various growth conditions, and additional inhibitor studies. Since the primary access of d -cycloserine in E. coli is via the d -alanine-glycine system, glycine might be expected to be a better antagonist of d -cycloserine inhibition than l -alanine. Glycine and d -alanine at 10 −5 m antagonized the effect of d -cycloserine in E. coli , whereas this concentration of l -alanine had no effect.
Wargel et al. (Tue,) studied this question.
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