The Impact of Sex on the Median Effective Dose of Dexmedetomidine for Preoperative Sedation in Adults Undergoing Upper Limb Surgery: An Up-and-Down Sequential Allocation Study

Purpose: ) of dexmedetomidine for preoperative sedation in adult men and women undergoing elective upper limb surgery. Patients and Methods: with supportive analyses including probit regression, bootstrap validation, and multivariable logistic regression adjusted for baseline covariates. Secondary outcomes included sedation depth and adverse events. Results: = 0.275), whereas dexmedetomidine dose was a significant predictor. At 26 minutes, neither MOAA/S scores nor bispectral index (BIS) values differed significantly between sexes. Bradycardia occurred in 39.1% of males versus 34.8% of females, and hypertension in 13.0% versus 4.3%, respectively; all adverse events were transient and safely managed. Conclusion: under standardized preoperative conditions. These findings do not support routine sex-based dose adjustment for preoperative sedation in relatively healthy adults.