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January 9, 2025Bulletin of the National Research Centre/Bulletin of the National Research Center8 citationsOpen Access

Machine learning algorithms for predictive modeling of dyslipidemia-associated cardiovascular disease risk in pregnancy: a comparison of boosting, random forest, and decision tree regression

ISIdris Zubairu SadiqFAFatima Sadiq AbubakarMSMuhammad Auwal Saliu

Key Result

Random forest regression outperformed boosting and decision tree models in predicting dyslipidemia-associated cardiovascular disease risk in pregnant women, achieving the lowest mean squared error of 0.071 and an R2 of 0.95.

Study Design

Type

Cross-Sectional (n=112)

Multicenter

No

Structured PICO

Do machine learning algorithms (random forest, boosting, decision tree) accurately predict dyslipidemia-associated cardiovascular disease risk in pregnant women?

P
Population
112 pregnant women aged between 15 and 49 attending the antenatal care unit at Aminu Kano Teaching Hospital, Kano, Nigeria. Exclusion criteria: HIV/AIDS, hypertension, diabetes, and hyperglycemia.
I
Intervention
Machine learning predictive modeling using random forest, boosting, and decision tree regression based on atherogenic index and lipid profile parameters.
C
Comparator
Comparison among the three machine learning algorithms (random forest vs. boosting vs. decision tree regression).
O
Outcome
Prediction accuracy of dyslipidemia-associated cardiovascular disease risk, evaluated by Mean Square Error (MSE), Root Mean Square Error (RMSE), and R-squared (R2).surrogate

Random forest regression provides highly accurate predictive modeling for dyslipidemia-associated cardiovascular disease risk in pregnant women using lipid profile parameters.

Limitations

  • Potential biases in data collection
  • Model assumptions
  • Issues with generalizability
  • Need for validation in diverse populations
  • Need to explore additional predictors to enhance model performance

Abstract

Abstract Background Cardiovascular diseases (CVD) are major contributors to maternal mortality and morbidity during pregnancy and increased atherogenic index of plasma levels is associated with a higher risk of CVD and obesity. Methods In this study, we utilized three different machine learning algorithms (boosting, random forest, and decision tree regression) to predict dyslipidemia-associated cardiovascular disease using atherogenic index and lipid profile parameters based on a cross-sectional study datasets of 112 pregnant women aged between 15 and 49 conducted at Aminu Kano Teaching Hospital. Results The results showed that random forest regression outperformed both boosting and decision tree regression, recording the lowest error criteria (MSE = 0.071 and RMSE = 0.266) for evaluating the model. These findings indicated that all the three algorithms have the potential to effectively model the data from atherogenic indices and lipid profile parameters but random forest and boosting were found to outperform decision tree models with respective R 2 values of 0.95 and 0.92. Conclusions Overall, the study highlights the accuracy of machine learning models (random forest, boosting, and decision trees) in predicting dyslipidemia-associated cardiovascular diseases and the findings could contribute to the development of effective strategies for the prevention and treatment of dyslipidemia-associated cardiovascular diseases.

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Cite This Study

Sadiq et al. (2025) conducted a cross-sectional in Dyslipidemia-associated cardiovascular disease risk in pregnancy (n=112). Random forest regression vs. Boosting and decision tree regression was evaluated on Prediction of dyslipidemia-associated cardiovascular disease risk (Mean Squared Error and R-squared). Random forest regression outperformed boosting and decision tree models in predicting dyslipidemia-associated cardiovascular disease risk in pregnant women, achieving the lowest mean squared error of 0.071 and an R2 of 0.95.

synapsesocial.com/papers/6a0ede5f9df4132b62f9c687https://doi.org/10.1186/s42269-024-01295-y
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