Why the study?
Does PCR analysis of myocardial tissue improve the detection of viral genomes in children with suspected acute myocarditis?
Population
34 children with suspected acute viral myocarditis and 17 control patients with congenital heart disease or…
Comparison
Polymerase chain reaction analysis of myocardial… vs Control patients without myocarditis; comparison…
Design
Case-control
Key result
PCR detected viral genomes in 68% of myocardial samples from children with suspected acute myocarditis, whereas all control samples were negative.
Authors
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Myocardial PCR may aid etiologic diagnosis in suspected pediatric myocarditis; leaves open effects on management.
Case-Control (n=51)
Does PCR analysis of myocardial tissue improve the detection of viral genomes in children with suspected acute myocarditis?
Absolute Event Rate: 68% vs 0%
PCR is a rapid and sensitive diagnostic method that enhances the detection of viral genomes, particularly adenovirus and enterovirus, in the myocardium of children with suspected acute myocarditis.
Martin et al. (1994) conducted a case-control in Acute viral myocarditis (n=51). Polymerase chain reaction (PCR) vs. Control patients was evaluated on Detection of viral genome in myocardial samples. PCR detected viral genomes in 68% of myocardial samples from children with suspected acute myocarditis, whereas all control samples were negative.