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It has been established that the base composition of deoxyribonucleic acid of various organisms shows a wide variation in its mean value (Lee, Wahl, and Barbu, 1956; Belozersky and Spirin, 1958). However, the distribution of the base composition of DNA molecules of an organism is generally unimodel, and the range is relatively narrow (Sueoka, Marmur, and Doty, 1959; Rolfe and Meselson, 1959). These features are particularly clear among bacterial species. Moreover, phylogenetic relations seem to be reflected in the DNA base composition (Lee, Wahl, and Barbu, 1956). Among bacteria the mean guanine-cytosine (GC) content varies approximately from 25 to 75 per cent, and the heterogeneity of the DNA molecules of each bacterial species is within about 5 per cent GC content on both sides of the mean value. These characteristics of variation and heterogeneity of DNA have served to confuse rather than illuminate our understanding of the coding mechanism between...
Noboru Sueoka (Sun,) studied this question.