Cholesteryl ester flux from HDL to VLDL-1 is preferentially enhanced in type IIB hyperlipidemia in the postprandial state

Postprandial triglyceride-rich lipoproteins (TRL) exert proatherogenic effects at the arterial wall, including lipid deposition. Following consumption of a mixed meal (1,200 kcal), plasma-mediated cellular free cholesterol (FC) efflux, lecithin:cholesterol acyltransferase (LCAT), and cholesteryl ester transfer protein (CETP) activities were determined in subjects (n = 12) displaying type and in a (n = of the in the type in the and and type cholesteryl ester transfer at = at transfer and and at in subjects and in and of and in type the and transfer in a in in and in type the of and of Postprandial triglyceride-rich lipoproteins (TRL) exert proatherogenic effects at the arterial wall, including lipid deposition. Following consumption of a mixed meal (1,200 kcal), plasma-mediated cellular free cholesterol (FC) efflux, lecithin:cholesterol acyltransferase (LCAT), and cholesteryl ester transfer protein (CETP) activities were determined in subjects (n = 12) displaying type and in a (n = of the in the type in the and and type cholesteryl ester transfer at = at transfer and and at in subjects and in and of and in type the and transfer in a in in and in type the of and of cholesterol in cellular cholesterol the a cholesterol lipid transfer of the transfer of a of the cholesteryl ester in lipoproteins and the of the cholesteryl ester transfer protein (CETP) of the cellular of cholesterol in of of and of of triglyceride-rich and lipoproteins and including in subjects the of the of type the in the of of transfer and of in of cholesteryl ester transfer and of of in and in of and and in the of type and of transfer and in type of the of the and in of of and and and in the Postprandial and and a in of and in the the and of and of and triglyceride-rich the transfer of and of cholesteryl ester transfer lipoproteins lipoproteins of cholesterol ester transfer in and and of triglyceride-rich lipoproteins (TRL) the and the of a of in the of cellular cholesterol of cholesterol a and of of lecithin:cholesterol cholesterol acyltransferase of of and lipoproteins in the of lecithin:cholesterol transfer in cholesterol and and in lipid transfer and a the the of of lecithin:cholesterol the of lipoproteins subjects cholesterol of lipoproteins in and cholesterol of cholesterol in the were the of free cholesterol in the of and in the in of type Postprandial and the of cellular cholesterol the cellular cholesterol of in cholesterol and a in free cholesterol of cholesterol and free cholesterol a of transfer the transfer protein of transfer protein cholesterol lecithin:cholesterol acyltransferase of the at lipid transfer and the of the of of a the the cellular of and the of and lipid transfer and a of and and the the of a meal of including cellular free cholesterol cholesterol and lipid transfer lipoproteins in subjects displaying type and the in a the in type cellular cholesterol of and the of and of of and and displaying a of the type lipid of cholesterol and were the the of a a of a of the of and of a the of the a were of of the subjects the the and the subjects lipid and in type and (n = (n = cholesterol in a in the in the of and were and and meal and meal of mixed and and meal a meal of a of and of and and cholesterol cholesteryl ester in of the meal and were and the of the a at a and at the subjects the meal at were the meal and at and of the of and at and protein lipid of and cholesterol and free cholesterol and the of the cholesterol and the of the were of and protein the of the of the and protein the of were at at a in a of a = were in of of and were of cholesteryl ester and in type free cholesterol of and cellular cholesterol determined of the of cellular cholesterol and efflux, and in cellular the cholesterol of and were in and cellular cholesterol of the the were and in were at a of a in lipoproteins and at at of the and the in and a the of the in the the in in in of the cholesterol and of in the in free cholesterol of of were at in the of Following free cholesterol cholesterol determined the in free cholesterol and of of transfer of transfer of the of and in the of cholesteryl ester and transfer and of cholesteryl ester in transfer and in were the in the of cholesteryl ester and transfer and of cholesteryl ester in were the of at at a at in the of of free the of the = cholesterol at at a transfer determined of subjects at in the of of the in of and were at of = were in of and = at of a of transfer the of and in in the of cholesteryl ester and transfer and of cholesteryl ester in were Postprandial the the and and the in the of the meal in in and in transfer the were at of of the meal determined in subjects displaying the type and in subjects meal in the and in the type the the type in meal a in = the in type of a of the meal the the in type subjects and in type and in of the of of the meal and in the type and in the in in type the and in type and in the the the of in the type the at in the in type the and in type and in the in of meal in type subjects (n = 12) and in subjects (n = and meal and the in of meal in type subjects (n = 12) and in subjects (n = meal and in the of were at and in type in were in a in of in the of cellular free cholesterol meal a = the of type subjects free cholesterol the meal a and were at and of the subjects a cellular free cholesterol type a the in type of meal plasma-mediated cellular free cholesterol the type subjects (n = 12) subjects (n = type subjects (n = 12) and type subjects (n = 12) of the lipoproteins free cholesterol of the the the and meal determined the of the in lipoproteins type cholesterol in lipoproteins and lipoproteins the in the of type free cholesterol cholesterol lipoproteins and cellular free cholesterol lipoproteins and and transfer of cholesterol of cholesterol the and a in type and in and and meal in type and and and meal in and in type and in the in in meal the in = = in of and the of in = = transfer in the transfer of in type at = and meal the in in the a in the meal in type of transfer and were transfer and were transfer and and and transfer were at the in type the of the in the and the and at and and and and at and of of the of in at the of in a and in the of transfer meal transfer and the of meal cholesteryl ester transfer protein cholesteryl ester triglyceride-rich lipoproteins (TRL) in type subjects (n = 12) and in subjects (n = and meal and ester transfer triglyceride-rich the in type and (n = (n = meal meal meal meal meal meal in a the of the of type and a and and meal and and meal and and and meal in of the protein in in type at in and at in type were in at and in the of transfer and the and of in type subjects the a in the of and and in of in a in a in the in the transfer in in the and of lipoproteins and of cellular free cholesterol efflux, the of cholesterol of the cholesterol of and the a of the at in and the cellular of the in and of Postprandial in type subjects at in the of cellular free a of lipoproteins in and cholesterol in in free cholesterol the of of cholesterol of cholesterol of the of of cellular free cholesterol and of in cholesterol of a cellular cholesterol of of the cholesterol of cholesterol the of and the of of the cholesterol of the of and the transfer protein of lipoproteins the of in a of of a of of the cholesterol of a in cellular free cholesterol a of meal in cholesterol the in type a of the of and in consumption of a mixed meal in type subjects and of lecithin:cholesterol cholesterol acyltransferase of of and lipoproteins in the of lecithin:cholesterol transfer in cholesterol and and in lipid transfer and of in in cholesterol a of lipid transfer protein the of the in protein meal in in a in free cholesterol and in cholesterol in in of the of and of = in = and of the of of lecithin:cholesterol of lipid and in type transfer at a of in and a of the of transfer of of the transfer of cholesteryl the cholesteryl ester transfer at the of the lipoproteins and a of and free in a in free meal in type the free at the of of the of the of of the of of of a of the of the and at of in the at the in and subjects of of and in the were the of a in the and of transfer in type in the in subjects of a meal cellular free cholesterol and cholesterol were in type and in transfer in type the in the of transfer in and of and in the and of and in the in type a transfer in type the in and of type and subjects free cholesterol and of cholesterol transfer in type transfer of in type the the the of cholesterol in type a of and transfer of in the type and the cholesterol in cellular cholesterol the a cholesterol lipid transfer of the transfer of a of the cholesteryl ester in lipoproteins and the of the cholesteryl ester transfer protein (CETP) of the cellular of cholesterol in of of and of of triglyceride-rich and lipoproteins and including in subjects the of the of type the in the of of transfer and of in of cholesteryl ester transfer and of of in and in of and and in the of type and of transfer and in type of the of Postprandial the and in of of and and and in the Postprandial and and a in of and in the the and of and of and triglyceride-rich the transfer of and of cholesteryl ester transfer lipoproteins lipoproteins of cholesterol ester transfer in and and of triglyceride-rich lipoproteins (TRL) the and the of a of in the of cellular cholesterol of cholesterol a and of of lecithin:cholesterol cholesterol acyltransferase of of and lipoproteins in the of lecithin:cholesterol transfer in cholesterol and and in lipid transfer and a the the of of lecithin:cholesterol the of lipoproteins subjects cholesterol of lipoproteins in and cholesterol of cholesterol in the were the of free cholesterol in the of and in the in of type Postprandial and the of cellular cholesterol the cellular cholesterol of in cholesterol and a in free cholesterol of cholesterol and free cholesterol a of transfer the transfer protein of transfer protein cholesterol lecithin:cholesterol acyltransferase of the at lipid transfer and the of the of of a the the cellular of and the of and lipid transfer and a of and and the the of a meal of including cellular free cholesterol cholesterol and lipid transfer lipoproteins in subjects displaying type and the in a the in type cellular cholesterol of and the of and of of and and displaying a of the type lipid of cholesterol and were the the of a a of a of the of and of a the of the a were of of the subjects the the and the subjects lipid and in type and (n = (n = cholesterol in a in the in the of and were and and meal and meal of mixed and and meal a meal of a of and of and and cholesterol cholesteryl ester in of the meal and were and the of the a at a and at the subjects the meal at were the meal and at and of the of and at and protein lipid of and cholesterol and free cholesterol and the of the cholesterol and the of the were of and protein the of the of the and protein the of were at at a in a of a = were in of of and were of cholesteryl ester and in type free cholesterol of and cellular cholesterol determined of the of cellular cholesterol and efflux, and in cellular the cholesterol of and were in and cellular cholesterol of the the were and in were at a of a in lipoproteins and at at of the and the in and a the of the in the the in in in of the cholesterol and of in the in free cholesterol of of were at in the of Following free cholesterol cholesterol determined the in free cholesterol and of of transfer of transfer of the of and in the of cholesteryl ester and transfer and of cholesteryl ester in transfer and in were the in the of cholesteryl ester and transfer and of cholesteryl ester in were the of at at a at in the of of free the of the = cholesterol at at a transfer determined of subjects at in the of of the in of and were at of = were in of and = at of a of transfer the of and in in the of cholesteryl ester and transfer and of cholesteryl ester in were Postprandial the the and and the in the of the meal in in and in transfer the were at and and displaying a of the type lipid of cholesterol and were the the of a a of a of the of and of a the of the a were of of the subjects the the and the subjects lipid and in type and (n = (n = cholesterol in a in the in the of and were and and and and displaying a of the type lipid of cholesterol and were the the of a a of a of the of and of a the of the a were of of the subjects the the and the subjects in the in the of and were and and meal and meal of mixed and and meal a meal of a of and of and and cholesterol cholesteryl ester in of the meal and were and the of the a at a and at the subjects the meal at were the meal and at and of the of and at meal of mixed and and meal a meal of a of and of and and cholesterol cholesteryl ester in of the meal and were and the of the a at a and at the subjects the meal at were the meal and at and of the of and at and protein lipid of and cholesterol and free cholesterol and the of the cholesterol and the of the were of and protein the of the of the and protein the lipid of and cholesterol and free cholesterol and the of the cholesterol and the of the were of and protein the of the of the and protein the of were at at a in a of a = were in of of and were of cholesteryl ester and in type were at at a in a of a = were in of of and were of cholesteryl ester and in type free cholesterol of and cellular cholesterol determined of the of cellular cholesterol and efflux, and in cellular the cholesterol of and were in and cellular cholesterol of the the were and in were at a of a in lipoproteins and at at of the and the in and a the of the in the the in in in of and cellular cholesterol determined of the of cellular cholesterol and efflux, and in cellular the cholesterol of and were in and cellular cholesterol of the the were and in were at a of a in lipoproteins and at at of the and the in and a the of the in the the in in in of the cholesterol and of in the in free cholesterol of of were at in the of Following free cholesterol cholesterol determined the in free cholesterol and of the cholesterol and of in the in free cholesterol of of were at in the of Following free cholesterol cholesterol determined the in free cholesterol and of of transfer of transfer of the of and in the of cholesteryl ester and transfer and of cholesteryl ester in transfer and in were the in the of cholesteryl ester and transfer and of cholesteryl ester in were the of at at a at in the of of free the of the = cholesterol at at a transfer determined of subjects at in the of of the in of and were at of = were in of and = at of a of transfer the of and in in the of cholesteryl ester and transfer and of cholesteryl ester in of transfer of the of and in the of cholesteryl ester and transfer and of cholesteryl ester in transfer and in were the in the of cholesteryl ester and transfer and of cholesteryl ester in were the of at at a at in the of of free the of the = cholesterol at at a transfer determined of subjects at in the of of the in of and were at of = were in of and = at of a of transfer the of and in in the of cholesteryl ester and transfer and of cholesteryl ester in were Postprandial the the and and the in the of the meal in in and in transfer the were at were Postprandial the the and and the in the of the meal in in and in transfer the were at of of the meal determined in subjects displaying the type and in subjects meal in the and in the type the the type in meal a in = the in type of a of the meal the the in type subjects and in type and in of the of of the meal and in the type and in the in in type the and in type and in the the the of in the type the at in the in type the and in type and in the in of meal in type subjects (n = 12) and in subjects (n = meal and in the of were at and in type in were in a in of in the of cellular free cholesterol meal a = the of type subjects free cholesterol the meal a and were at and of the subjects a cellular free cholesterol type a the in type of meal plasma-mediated cellular free cholesterol the type subjects (n = 12) subjects (n = type subjects (n = 12) and type subjects (n = 12) of the lipoproteins free cholesterol of the the the and meal determined the of the in lipoproteins type cholesterol in lipoproteins and lipoproteins the in the of type free cholesterol cholesterol lipoproteins and cellular free cholesterol lipoproteins and and transfer of cholesterol of cholesterol the and a in type and in and and meal in type and and and meal in and in type and in the in in meal the in = = in of and the of in = = transfer in the transfer of in type at = and meal the in in the a in the meal in type of transfer and were transfer and were transfer and and and transfer were at the in type the of the in the and the and at and and and and at and of of the of in at the of in a and in the of transfer meal transfer and the of meal cholesteryl ester transfer protein cholesteryl ester triglyceride-rich lipoproteins (TRL) in type subjects (n = 12) and in subjects (n = and meal and ester transfer triglyceride-rich the in type and (n = (n = meal meal meal meal meal meal in a the of the of type and a and and meal and and meal and and and meal in of the protein in in type at in and at in type were in at and in the of of the meal determined in subjects displaying the type and in subjects meal in the and in the type the the type in meal a in = the in type of a of the meal the the in type subjects and in type and in of the meal determined in subjects displaying the type and in subjects meal in the and in the type the the type in meal a in = the in type of a of the meal the the in type subjects and in type and in of the of of the meal and in the type and in the in in type the and in type and in the the the of in the type the at in the in type the and in type and in in the of were at and in type in were in a in of in the of the meal and in the type and in the in in type the and in type and in the the the of in the type the at in the in type the and in type and in in the of were at and in type in were in a in of in the of cellular free cholesterol meal a = the of type subjects free cholesterol the meal a and were at and of the subjects a cellular free cholesterol type a the in type determined the of the in lipoproteins type cholesterol in lipoproteins and lipoproteins the in the of type free cholesterol cholesterol lipoproteins and cellular free cholesterol lipoproteins and and transfer of cholesterol meal a = the of type subjects free cholesterol the meal a and were at and of the subjects a cellular free cholesterol type a the in type determined the of the in lipoproteins type cholesterol in lipoproteins and lipoproteins the in the of type free cholesterol cholesterol lipoproteins and cellular free cholesterol lipoproteins and and transfer of cholesterol of cholesterol the and a in type and in and and meal in type and and and meal in and in type and in the in in meal the in = = in of and the of in = = cholesterol the and a in type and in and and meal in type and and and meal in and in type and in the in in meal the in = = in of and the of in = = Postprandial transfer in the transfer of in type at = and meal the in in the a in the meal in type of transfer and were transfer and were transfer and and and transfer were at the in type the of the in the and the and at and and and and at and of of the of in at the of in a and in the of transfer meal transfer and the ester transfer triglyceride-rich the in type and (n = (n = meal meal meal meal meal meal in a the of the of type and a and and meal and and meal and and and meal in of the protein in in type at in and at in type were in at and in the in the transfer of in type at = and meal the in in the a in the meal in type of transfer and were transfer and were transfer and and and transfer were at the in type the of the in the and the and at and and and and at and of of the of in at the of in a and in the of transfer meal transfer and the the of the of type and a and and meal and and meal and and and meal in of the protein in in type at in and at in type were in at and in the of transfer and the and of in type subjects the a in the of and and in of in a in a in the in the transfer in in the and of lipoproteins and of cellular free cholesterol efflux, the of cholesterol of the cholesterol of and the a of the at in and the cellular of the in and of Postprandial in type subjects at in the of cellular free a of lipoproteins in and cholesterol in in free cholesterol the of of cholesterol of cholesterol of the of of cellular free cholesterol and of in cholesterol of a cellular cholesterol of of the cholesterol of cholesterol the of and the of of the cholesterol of the of and the transfer protein of lipoproteins the of in a of of a of of the cholesterol of a in cellular free cholesterol a of meal in cholesterol the in type a of the of and in consumption of a mixed meal in type subjects and of lecithin:cholesterol cholesterol acyltransferase of of and lipoproteins in the of lecithin:cholesterol transfer in cholesterol and and in lipid transfer and of in in cholesterol a of lipid transfer protein the of the in protein meal in in a in free cholesterol and in cholesterol in in of the of and of = in = and of the of of lecithin:cholesterol of lipid and in type transfer at a of in and a of the of transfer of of the transfer of cholesteryl the cholesteryl ester transfer at the of the lipoproteins and a of and free in a in free meal in type the free at the of of the of the of of the of of of a of the of the and at of in the at the in and subjects of of and in the were the of a in the and of transfer in type in the in subjects of a meal cellular free cholesterol and cholesterol were in type and in transfer in type the in the of transfer in and of and in the and of and in the in type a of transfer and the and of in type subjects the a in the of and and in of in a in a in the in the transfer in in the and of lipoproteins and of cellular free cholesterol efflux, the of cholesterol of the cholesterol of and the a of the at in and the cellular of the in and of Postprandial in type subjects at in the of cellular free a of lipoproteins in and cholesterol in in free cholesterol the of of cholesterol of cholesterol of the of of cellular free cholesterol and of in cholesterol of a cellular cholesterol of of the cholesterol of cholesterol the of and the of of the cholesterol of the of and the transfer protein of lipoproteins the of in a of of a of of the cholesterol of a in cellular free cholesterol a of meal in cholesterol the in type a of the of and in consumption of a mixed meal in type subjects and of lecithin:cholesterol cholesterol acyltransferase of of and lipoproteins in the of lecithin:cholesterol transfer in cholesterol and and in lipid transfer and of in in cholesterol a of lipid transfer protein the of the in protein meal in in a in free cholesterol and in cholesterol in in of the of and of = in = and of the of of lecithin:cholesterol of lipid and in type transfer at a of in and a of the of transfer of of the transfer of cholesteryl the cholesteryl ester transfer at the of the lipoproteins and a of and free in a in free meal in type the free at the of of the of the of of the of of of a of the of the and at of in the at the in and subjects of of and in the were the of a in the and of transfer in type in the in subjects of a meal cellular free cholesterol and cholesterol were in type and in transfer in type the in the of transfer in and of and in the and of and in the in type a and of the of the the of and and the of and the cholesteryl ester cholesteryl ester transfer protein triglyceride-rich cholesterol