Pulsed-field ablation causes distinct cellular injury and lesion progression from acute to chronic maturation states compared to thermal ablation modalities.
This review provides a comprehensive overview of the cellular mechanisms of injury, lesion progression, and clinical indicators associated with cardiac pulsed-field ablation compared to thermal modalities.
As pulsed-field ablation (PFA) emerges as a promising therapy for atrial arrhythmias, an understanding of the cellular injury to cardiac tissue is critical to evaluating and interpreting results for each PFA system. This review aims to detail the mechanism of cell death for PFA, compare the cell death mechanism to thermal ablation modalities, clarify common histology markers, detail the progression of PFA lesions from the acute, to subacute, to chronic maturation states, and discuss clinical indicators of PFA lesions.
Garrott et al. (Mon,) conducted a review in Atrial arrhythmias. Pulsed-field ablation (PFA) vs. Thermal ablation modalities was evaluated. Pulsed-field ablation causes distinct cellular injury and lesion progression from acute to chronic maturation states compared to thermal ablation modalities.
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