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September 30, 2013Res MedicaOpen Access

While the overall risk of myocardial infarction is not reduced by anti-TNF therapy in rheumatoid arthritis patients, those who respond to the treatment display a significant reduction in myocardial infarction risk.

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Why the study?

Does anti-TNF therapy reduce myocardial infarction in patients with rheumatoid arthritis?

Population

Patients with rheumatoid arthritis

Comparison

Anti-TNF therapy vs Traditional disease-modifying antirheumatic…

Design

Review

Key result

While the overall risk of myocardial infarction is not reduced by anti-TNF therapy in rheumatoid arthritis patients, those who respond to the treatment display a significant reduction in myocardial infarction risk.

Authors

LYLi Tian Yeo

Discussion

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Member takes

Overview

Response to anti-TNF may identify RA patients at lower MI risk; leaves open causal cardiovascular benefit.

Structured PICO

Does anti-TNF therapy reduce myocardial infarction in patients with rheumatoid arthritis?

P
Population
Patients with rheumatoid arthritis
I
Intervention
Anti-TNF therapy (e.g., infliximab, etanercept, adalimumab, golimumab, certolizumab)
C
Comparator
Traditional disease-modifying antirheumatic drugs (DMARDs) or no DMARDs
O
Outcome
Myocardial infarctionhard clinical

Anti-TNF therapy may reduce the risk of myocardial infarction specifically in rheumatoid arthritis patients who respond to the treatment, though its overall effect on cardiovascular risk remains unproven.

Limitations

  • Use of mainly infliximab in studies of anti-TNF therapy, which may not reflect other anti-TNF therapies
  • Focuses only on rheumatoid arthritis, limiting generalizability to other inflammatory rheumatic disorders
  • Lack of statistical techniques to collectively conclude the results from the studies used
  • Use of mainly infliximab in studies, which may not reflect the effects of other anti-TNF therapies
  • Focuses only on rheumatoid arthritis, excluding other inflammatory rheumatic disorders

Cite This Study

Li Tian Yeo (2013) conducted a review in Rheumatoid Arthritis. TNF Antagonists was evaluated. While the overall risk of myocardial infarction is not reduced by anti-TNF therapy in rheumatoid arthritis patients, those who respond to the treatment display a significant reduction in myocardial infarction risk.

synapsesocial.com/papers/6a11e53073c5a8f747a5695ehttps://doi.org/10.2218/resmedica.v21i1.185
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