Longitudinal changes in cholesterol and triglyceride levels were better predictors of incident ischemic heart disease (44 events among 1437 men) than initial lipid or systolic blood pressure levels.
Cohort (n=1,437)
No
Do longitudinal changes in cholesterol and triglyceride levels predict the subsequent development of ischemic heart disease better than initial levels in men?
Longitudinal changes in lipid levels are stronger predictors of future ischemic heart disease than single baseline measurements, highlighting the importance of monitoring lipid trajectories over time.
We examined the relation of longitudinal changes in cholesterol and triglyceride to the subsequent development of heart disease. The data were from 1437 participants of the Normative Aging Study, a prospective study of men from the Boston area who were free of ischemic heart disease on two examinations approximately 5 years apart. Forty-four had symptoms or ECG findings of ischemic heart disease after their second but before their third examination, a period of 3-5 years. The risk of heart disease was studied using a multiple logistic risk model that took into account smoking and other risk factors. Changes in cholesterol and triglyceride levels between Exams 1 and 2, when corrected for regression to the mean, were better predictors of heart disease incurred between Exams 2 and 3 than initial levels of cholesterol, triglyceride or systolic blood pressure. When two age groups (28-52 years and 53-85 years) were considered, changes were important predictors in each age group. These findings suggest the importance of monitoring lipid changes over time.
Glynn et al. (Fri,) conducted a cohort in Ischemic heart disease (n=1,437). Longitudinal changes in cholesterol and triglyceride vs. Initial levels of cholesterol, triglyceride or systolic blood pressure was evaluated on Subsequent development of ischemic heart disease (symptoms or ECG findings). Longitudinal changes in cholesterol and triglyceride levels were better predictors of incident ischemic heart disease (44 events among 1437 men) than initial lipid or systolic blood pressure levels.