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Abstract. Among 61 polycythaemic patients treated with chlornaphazine ten developed bladder tumours. Atypical cells have been demonstrated in the urines of another five. The induction period for tumour development was from approximately 3 to 10 years, rather independently of the total dose. Therefore, a careful follow‐up over a period of many years is necessary for patients who have received this treatment, even for low total doses. The most important link in the follow‐up is urinary examination for tumour cells.
Thiede et al. (Sun,) studied this question.
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