What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Cardiovascular risk factors (n=20324). Intervention: Time period (2012) vs. Time period (2007). Primary outcome: Framingham 10-year risk for CVD in men (p=<0.0001).

What does this research mean for the field?

Between 2007 and 2012, the estimated Framingham 10-year risk for cardiovascular disease and the prevalence of key risk factors like hypertension and smoking decreased significantly in a large, untreated French urban population. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 23, 2015PLoS ONE25 citationsOpen Access

Trends in Cardiovascular Disease Risk Factor Prevalence and Estimated 10-Year Cardiovascular Risk Scores in a Large Untreated French Urban Population: The CARVAR 92 Study

Q: What are the key findings of this study?

Between 2007 and 2012, the estimated Framingham 10-year risk for cardiovascular disease in an untreated French urban population decreased significantly from 13.3% to 11.7% in men and from 8.0% to 5.9% in women.

Q: What does this research mean for the field?

Between 2007 and 2012, the estimated Framingham 10-year risk for cardiovascular disease and the prevalence of key risk factors like hypertension and smoking decreased significantly in a large, untreated French urban population. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

CKCarma KaramUniversité de Versailles Saint-Quentin-en-Yvelines ABAlain BeauchetInserm SCSébastien CzernichowInserm

Key Result

Between 2007 and 2012, the estimated Framingham 10-year risk for cardiovascular disease in an untreated French urban population decreased significantly from 13.3% to 11.7% in men and from 8.0% to 5.9% in women.

Study Design

Type

Cross-Sectional (n=20,324)

Multicenter

Yes

Structured PICO

Population

20,324 participants (men aged 40 to 65 years and women aged 50 to 70 years) in the western suburbs of Paris, including 14,709 untreated individuals not taking antihypertensive, lipid-lowering, or diabetes medications.

Outcome

Changes in cardiovascular risk factors (hypertension, smoking, diabetes, high LDL-C, obesity) and estimated 10-year risk for CVD (Framingham) and fatal CVD (SCORE) between 2007 and 2012.surrogate

Over a 6-year period, the prevalence of several cardiovascular risk factors and estimated 10-year CVD risk decreased significantly in an untreated French urban population, highlighting the potential impact of community prevention programs.

Main Result

Absolute Event Rate: 11.7% vs 13.3%

p-value: p=<0.0001

Limitations

No follow-up data to assess the possible correction of the detected cardiovascular risk factors
Choice of selected age groups required age adjustment
Not designed as a longitudinal assessment, but rather as a cross-sectional survey spanning several years
Possibility of selection bias and self-selection bias by respondents
No data were available on dietary habits and physical activity
No follow-up data to assess correction of detected CVRFs
Choice of selected age groups requiring age adjustment
Not designed as a longitudinal assessment
Possibility of selection bias and self-selection bias
No data available on dietary habits and physical activity

Abstract

BACKGROUND: Surveys measuring effectiveness of public awareness campaigns in reducing cardiovascular disease (CVD) incidence have yielded equivocal findings. The aim of this study was to describe cardiovascular risk factors (CVRFs) changes over the years in an untreated population-based study. METHODS: Between 2007 and 2012, we conducted a screening campaign for CVRFs in men aged 40 to 65 yrs and women aged 50 to 70 yrs in the western suburbs of Paris. Data were complete for 20,324 participants of which 14,709 were untreated. RESULTS: The prevalence trend over six years was statistically significant for hypertension in men from 25.9% in 2007 to 21.1% in 2012 (p=0.002) and from 23% in 2007 to 12.7% in 2012 in women (p<0.0001). The prevalence trend of tobacco smoking decreased from 38.6% to 27.7% in men (p=0.0001) and from 22.6% to 16.8% in women (p=0.113). The Framingham 10-year risk for CVD decreased from 13.3 ± 8.2 % in 2007 to 11.7 ± 9.0 % in 2012 in men and from 8.0 ± 4.1 % to 5.9 ± 3.4 % in women. The 10-year risk of fatal CVD based on the European Systematic COronary Risk Evaluation (SCORE) decreased in men and in women (p <0.0001). CONCLUSIONS: Over a 6-year period, several CVRFs have decreased in our screening campaign, leading to decrease in the 10-year risk for CVD and the 10-year risk of fatal CVD. Cardiologists should recognize the importance of community prevention programs and communication policies, particularly tobacco control and healthier diets to decrease the CVRFs in the general population.

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Cite This Study

Karam et al. (2015) conducted a cross-sectional in Cardiovascular risk factors (n=20,324). Time period (2012) vs. Time period (2007) was evaluated on Framingham 10-year risk for CVD in men (p=<0.0001). Between 2007 and 2012, the estimated Framingham 10-year risk for cardiovascular disease in an untreated French urban population decreased significantly from 13.3% to 11.7% in men and from 8.0% to 5.9% in women.

synapsesocial.com/papers/6a1275abea48cb855a34e2a4 https://doi.org/10.1371/journal.pone.0124817

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