What is the clinical evidence from this study?

Study design: RCT. Population: Coronary Heart Disease (n=28). Intervention: High intensity interval exercise (HII) vs. Moderate intensity continuous aerobic exercise (MIC). Primary outcome: Change in oxygen pulse (O2P) (p=<0.05).

May 20, 2017Open Access

Comparison of High Intensity Interval to Moderate Intensity Continuous Aerobic Exercise on Ventilatory Markers in Coronary Heart Disease Patients: A Randomized Controlled Study

Q: What are the key findings of this study?

High intensity interval exercise significantly improved oxygen pulse by 21% compared to a 1% change with moderate intensity continuous exercise in patients with coronary heart disease.

Q: What does this research mean for the field?

High intensity interval exercise significantly improves oxygen pulse by 21% compared to a 1% change with moderate intensity continuous exercise in patients with coronary heart disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Key Result

High intensity interval exercise significantly improved oxygen pulse by 21% compared to a 1% change with moderate intensity continuous exercise in patients with coronary heart disease.

Study Design

Type

RCT (n=28)

Blinding

Single-blind

Randomization

Randomized

Multicenter

Structured PICO

Does high intensity interval exercise improve ventilatory markers compared to moderate intensity continuous exercise in patients with mild to moderate coronary heart disease?

Population

28 patients with mild to moderate coronary heart disease (CHD), aged 50-60 years, ejection fraction >50%. Excluded: acute myocardial infarction or revascularization (<90 days), pacemakers, heart failure, musculoskeletal limitations, and changes in medication. Selected from the cardiac rehabilitation unit, Cairo University Hospitals.

Intervention

High intensity interval (HII) treadmill aerobic exercise, 3 times/week for 12 weeks. Protocol: 5 minutes warm up, 30 minutes of HII (interchanging 60% maxHR and 90% maxHR workloads every 2 minutes).

Comparator

Moderate intensity continuous (MIC) treadmill aerobic exercise, 3 times/week for 12 weeks. Protocol: 5 minutes warm up, 30 minutes of continuous aerobic exercise at 70 to 75% of peak HR, and 5 minutes cool down.

Outcome

Ventilatory markers (peak VO2, slope of VE/VCO2, OUES, and O2P) measured by cardiopulmonary exercise test at 12 weeks.surrogate

High intensity interval exercise significantly improves peak VO2 and oxygen pulse compared to moderate intensity continuous exercise in patients with mild to moderate coronary heart disease.

Main Result

Absolute Event Rate: 21% vs 1%

p-value: p=<0.05

Limitations

Small sample size
Included patients with only mild or moderate CHD
High baseline ejection fraction (approximately 63%) may have influenced the effects of exercise on ventilatory variables
Lack of additional ventilatory variables for ventricular function, lung perfusion, and arterial blood gases to determine underlying mechanisms

Abstract

Objectives: This study aim was to compare the impacts of high intensity interval (HII) to moderate intensity continuous exercise (MIC) on ventilatory markers in patients with coronary heart disease (CHD).

AIに質問

Bookmark

View Full Paper