Male Fbn1 C1041G/+ mice exhibited more severe thoracic aortopathy compared to females, with significantly increased proximal aortic diameter at 12 months versus wild-type mice (2.11 mm vs 1.58 mm, p=0.0007).
Absolute Event Rate: 2.11% vs 1.58%
p-value: p=0.0007
Male Fbn-1 C1041G/+ mice show more severe thoracic aortic changes compared with females, especially at 12 mo of age. Up to 6 mo of age, Sca-1 + smooth muscle progenitor cells are more abundant in the adventitia of both male and female Fbn-1 Het mice compared with wild types (WTs). Male and female Het mice show similar patterns of expression of Sca-1 + cells at early ages.
Gharraee et al. (Fri,) conducted a other in Marfan syndrome (n=80). Fbn1 C1041G/+ mutation vs. Wild-type (WT) mice was evaluated on Proximal aortic diameter at 12 months in male mice (mm) (p=0.0007). Male Fbn1 C1041G/+ mice exhibited more severe thoracic aortopathy compared to females, with significantly increased proximal aortic diameter at 12 months versus wild-type mice (2.11 mm vs 1.58 mm, p=0.0007).