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This paper aims to describe the rare occurrence of primary intracranial myxopapillary ependymomas and their characteristics.

May 25, 2026Frontiers in Oncology0 citationsOpen Access

Primary intracranial myxopapillary ependymoma: two case reports and literature review

ZLZhong LanCommand Hospital ZXZhen XuCommand Hospital SYShiyuan YinCommand Hospital

Key Points

This paper aims to describe the rare occurrence of primary intracranial myxopapillary ependymomas and their characteristics.
Presented two case reports of isolated myxopapillary ependymomas located in the frontal lobe.
Conducted a literature review to analyze clinical characteristics, imaging findings, and pathological features.
Both cases demonstrated typical histological features of myxopapillary ependymoma.
Imaging findings indicated isolated tumors in the cerebral parenchyma, emphasizing their rarity.
Clinical analysis provided insights for better recognition and understanding of this tumor type.

Abstract

Myxopapillary ependymoma (MPE), a histological variant of ependymoma, is characterized by a radial arrangement of spindled or epithelioid tumor cells surrounding blood vessels, accompanied by perivascular myxoid changes and microcyst formation. MPE typically occurs in young adults, predominantly in the conus medullaris, cauda equina, and filum terminale. However, primary intracranial MPEs, especially those arising in the cerebral parenchyma, are exceptionally rare. Here, we present two cases of isolated MPEs located in the frontal lobe to underscore their extraordinary rarity. We provide a comprehensive analysis of their clinical characteristics, imaging findings, and pathological features to deepen the understanding and recognition of this rare entity.

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