Human induced pluripotent stem cell-derived cardiomyocytes offer a valuable human-based electrophysiological model, but their application is challenged by biological differences from adult cardiomyocytes.
Provides a perspective on the opportunities and methodological challenges of using hiPSC-CMs as an electrophysiological model in cardiovascular research.
Models based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) are proposed in almost any field of physiology and pharmacology. The development of human induced pluripotent stem cell-derived cardiomyocytes is expected to become a step forward to increase the translational power of cardiovascular research. Importantly they should allow to study genetic effects on an electrophysiological background close to the human situation. However, biological and methodological issues revealed when human induced pluripotent stem cell-derived cardiomyocytes were used in experimental electrophysiology. We will discuss some of the challenges that should be considered when human induced pluripotent stem cell-derived cardiomyocytes will be used as a physiological model.
Ismaili et al. (Thu,) conducted a review in Cardiac electrophysiology. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) vs. Adult human cardiomyocytes was evaluated. Human induced pluripotent stem cell-derived cardiomyocytes offer a valuable human-based electrophysiological model, but their application is challenged by biological differences from adult cardiomyocytes.