Diabetes mellitus in patients undergoing CABG was not associated with increased early mortality (2.2% vs 3.1%; OR 0.44) but was associated with increased long-term mortality (RR 1.87, CI 1.60-2.14).
Cohort (n=1,025)
Does diabetes mellitus increase the risk of morbidity and mortality in patients undergoing coronary artery bypass surgery?
Diabetes mellitus is associated with increased long-term mortality after CABG, but does not significantly increase the risk of early mortality or perioperative complications.
Effect estimate: OR 0.44 (95% CI 0.05-3.56)
Absolute Event Rate: 2.2% vs 3.1%
Of 1025 patients (912 men, 113 women) who underwent coronary artery bypass grafting and were followed up for a mean of 7.4 years, 45 (4.4%) had diabetes mellitus. Norwegian population is 1.8-2%). Early mortality was not significantly greater among diabetics than in non-diabetics (2.2 vs. 3.1%, odds ratio--OR-0.44, confidence interval--CI- 0.05-3.56). Diabetic patients had no increased risk of perioperative myocardial infarction (OR = 0.87, CI 0.36-2.10) or of low-output syndrome necessitating intraortic balloon pumping (OR = 0.42, CI 0.55-3.05), and no excess incidence of late non-fatal myocardial infarction (relative risk = 0.69, CI 0.10-1.28) or late chronic heart failure (OR = 2.50, CI 0.5-11.0). Long-term mortality was increased in the diabetic patients (relative risk 1.87, CI 1.60-2.14). Thus diabetes did not entail heightened risk of early mortality, perioperative myocardial infarction or low-output syndrome. Nor was there excess risk of recurrent angina pectoris, late non-fatal myocardial infarction or chronic heart failure among the diabetic patients, but the late mortality risk was increased.
Risum et al. (1996) conducted a cohort in Coronary artery bypass grafting (n=1,025). Diabetes mellitus vs. Non-diabetics was evaluated on Early mortality (OR 0.44, 95% CI 0.05-3.56). Diabetes mellitus in patients undergoing CABG was not associated with increased early mortality (2.2% vs 3.1%; OR 0.44) but was associated with increased long-term mortality (RR 1.87, CI 1.60-2.14).