Atherosclerotic peripheral vascular disease in nondiabetic men was associated with a higher transcapillary escape rate of albumin compared to healthy controls (10.7 vs 7.4 %/h, P<0.013).
Observational (n=41)
Are systemic capillary permeability and albuminuria altered in nondiabetic men with atherosclerotic peripheral vascular disease compared to healthy controls?
Systemic capillary permeability is altered in nondiabetic atherosclerotic patients independently of blood pressure, but this abnormality is not reflected by proportionate changes in albuminuria.
Absolute Event Rate: 10.7% vs 7.4%
p-value: p=<0.013
Increased urine albumin is associated with atherosclerotic disease and predicts cardiovascular morbidity and mortality in nondiabetic populations. This finding is frequently postulated to reflect the impact of atherosclerotic damage on glomerular and systemic capillary permeability, an interesting but as yet untested hypothesis. The transcapillary escape rate of albumin (TERalb, the 1-hour decline rate of intravenous 125I-albumin, a measure of capillary macromolecular permeability), albuminuria, lipid levels, echocardiographic wall thickness, and insulin responses to oral glucose were measured in 30 untreated dipstick-negative lean men and clinically stable atherosclerotic peripheral vascular disease; tolerance to oral glucose was a requirement for inclusion in the study. Because hypertension per se might influence TERalb, the sample included either normotensive (n=18, 118+/-6/72+/-7 mm Hg) or hypertensive (n=12, 141+/-7/84+/-6 mmHg by 24-hour blood pressure monitoring) arteriopathic patients; 11 normal age- and gender-matched subjects (121+/-7/76+/-5 mmHg) were used as control subjects. TERalb was higher in patients (10.7+/-3.2 versus 7.4+/-1.7%/h, P<0.013), a difference that persisted after postload glucose, insulin, and lipid levels were accounted for by covariance analysis; atherosclerosis and hypertension together did not further impair vascular permeation to albumin. In contrast with TERalb, albuminuria was elevated only in the hypertensive subgroup; the 2 variables showed no relationship, even when the data were analyzed separately in normotensive and hypertensive subgroups. Urine albumin correlated positively with 24-hour blood pressure and wall thickness. Thus, systemic capillary permeability is altered in nondiabetic atherosclerotic patients independently from blood pressure levels, but this abnormality is not reflected by proportionate changes in albuminuria.
Pedrinelli et al. (Sat,) conducted a observational in Atherosclerotic peripheral vascular disease (n=41). Atherosclerotic peripheral vascular disease vs. Normal age- and gender-matched subjects was evaluated on Transcapillary escape rate of albumin (TERalb) (p=<0.013). Atherosclerotic peripheral vascular disease in nondiabetic men was associated with a higher transcapillary escape rate of albumin compared to healthy controls (10.7 vs 7.4 %/h, P<0.013).