Isolated diastolic hypertension was not significantly associated with target organ damage, such as NTproBNP levels (OR 1.04; 95% CI 0.82-1.32; p=0.750), compared to normotension.
Cross-Sectional (n=1,605)
Is isolated diastolic hypertension associated with target organ damage compared to normal blood pressure?
Isolated diastolic hypertension, as defined by the 2017 ACC/AHA guidelines, is not significantly associated with target organ damage, suggesting it may contribute marginally to cardiovascular risk.
Effect estimate: OR 1.04 (95% CI 0.82-1.32)
p-value: p=0.750
Abstract Background Isolated diastolic hypertension (IDH) is defined as diastolic blood pressure (DBP) ≥80 mmHg and systolic blood pressure (SBP) 80 mmHg); isolated systolic hypertension (ISH: SBP ≥130/DBP <80 mmHg). The association between hypertension status and TOD was assessed by multivariable‐adjusted logistic models. Results Using normotension as reference, IDH was not significantly associated with NTproBNP levels (adjusted odds ratio OR 1.04 95%CI 0.82;1.32, p = .750), microalbuminuria (OR 0.99 0.69; 1.42, p = .960), diastolic dysfunction (OR 1.53 0.88; 2.68, p = .130), left ventricular (LV) mass index (OR per 10 g/m 2 increase 1.07 0.95; 1.21, p = .250), LV longitudinal strain (global: OR 1.07 0.99; 1.14, p = .054; subendocardial: OR 1.06 0.99; 1.13, p = .087), carotid intima media thickness (OR 1.27 0.79; 2.06, p = .320), reduced ankle‐brachial index (<0.9; OR 1.59 0.19; 13.55, p = .670) and pulse wave velocity (PWV; OR 1.07 0.93; 1.23, p = .360). In contrast, combined hypertension and ISH were independently associated with LV mass index and PWV increase (all p ≤ .01). Conclusions IDH was not significantly associated with TOD. Further studies are needed to clarify the clinical role of IDH. Registration: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT01391442.
Monzo et al. (Wed,) conducted a cross-sectional in Isolated diastolic hypertension (n=1,605). Isolated diastolic hypertension vs. Normal blood pressure was evaluated on Target organ damage (e.g., NTproBNP levels) (OR 1.04, 95% CI 0.82-1.32, p=0.750). Isolated diastolic hypertension was not significantly associated with target organ damage, such as NTproBNP levels (OR 1.04; 95% CI 0.82-1.32; p=0.750), compared to normotension.