What does this research mean for the field?

In patients with Brugada syndrome, those with programmed electrical stimulation (PES)-induced ventricular fibrillation exhibit attenuated sinus node function and prolonged His-ventricle intervals compared to those without induced fibrillation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2004Open Access

Sinus Node Function in Patients With Brugada-Type ECG

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Brugada syndrome (n=60). Intervention: PES-induced ventricular fibrillation (VF group) vs. No PES-induced VF (non-VF group) and control group. Primary outcome: Sinus node function and His-ventricle interval.

Key Result

PES-induced ventricular fibrillation in Brugada syndrome was associated with attenuated sinus node function (corrected sinus node recovery time 452 vs 324 ms) and prolonged His-ventricle intervals.

Study Design

Type

Observational (n=60)

Structured PICO

Do patients with Brugada-type ECG and PES-induced ventricular fibrillation have more attenuated sinus node and AV node function compared to those without PES-induced VF?

Population

60 patients (59 male, 1 female) with Brugada-type ECG (13 symptomatic, 47 asymptomatic), mean age 47±10 years.

Intervention

Programmed electrical stimulation (PES) inducing ventricular fibrillation (n=26)

Comparator

Programmed electrical stimulation (PES) not inducing ventricular fibrillation (n=34)

Outcome

Sinus node function (corrected sinus node recovery time, sino-atrial conduction time) and atrioventricular node conduction (His-ventricle interval)surrogate

Patients with Brugada-type ECG and PES-induced ventricular fibrillation exhibit latent sinus node dysfunction and prolonged His-ventricular conduction, suggesting more extensive conduction system disease.

Abstract

BACKGROUND: Some studies have shown that patients with Brugada syndrome (BS) have atrioventricular conduction disturbance, but their sinus node function has not been evaluated. METHODS AND RESULTS: The patients group consisted of 59 male patients and 1 female patient with BS. Supraventricular and ventricular programmed electrical stimulation (PES) was performed. Ventricular fibrillation (VF) or sustained polymorphic ventricular tachycardia was induced by ventricular PES in 26 patients with BS (VF group), but was not induced in the other 34 patients (non-VF group). Sinus node function and conduction of the atrioventricular (AV) node in the control group, non-VF group and VF group were evaluated. Sinus node function was attenuated and the His - ventricle interval was prolonged in the VF group (corrected sinus node recovery time: 452+/-126 ms (VF group), 324+/-146 ms (non-VF group), Sino-atrial conduction time: 179+/-60 ms (VF group), 127+/-60 ms (non-VF group), His-ventricle interval: 41+/-9 ms (VF group), 35+/-8 ms (non-VF group)). CONCLUSION: The function of both the sinus node and AV node are attenuated in patients with PES-induced VF.

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Cite This Study

Morita et al. (Thu,) conducted a observational in Brugada syndrome (n=60). PES-induced ventricular fibrillation (VF group) vs. No PES-induced VF (non-VF group) and control group was evaluated on Sinus node function and His-ventricle interval. PES-induced ventricular fibrillation in Brugada syndrome was associated with attenuated sinus node function (corrected sinus node recovery time 452 vs 324 ms) and prolonged His-ventricle intervals.

synapsesocial.com/papers/6a15f796a215942ca9e3ee25 https://doi.org/https://doi.org/10.1253/circj.68.473

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