Synthetic atrial natriuretic factor (3-300 nM) decreased perfusion pressure and relaxed isolated cat coronary arteries in a concentration-dependent manner without directly altering myocardial performance.
Does synthetic atrial natriuretic factor induce coronary vasodilation and alter myocardial performance in isolated cat coronary arteries and papillary muscles?
Synthetic ANF acts as a direct coronary vasodilator without altering myocardial contractility in feline in vitro models.
The pharmacological activities of synthetic atrial natriuretic factor (ANF) on cat coronary artery were studied in vitro. In the preparation of isolated cat coronary artery perfused at a constant flow, ANF (3-300 nM) decreased perfusion pressure in a concentration dependent manner, indicating coronary vasodilating activity. ANF also relaxed feline coronary strips when contracted by U-46,619, CTA2, angiotensin II, serotonin, leukotriene C4 and D4. This relaxant effect was independent in the presence of endothelial cells and occurred in the presence of guanylate cyclase inhibitor, methylene blue. ANF had no direct effect on electrically driven isolated cat papillary muscles signifying a lack of direct inotropic activity. It can be concluded that ANF may potentiate coronary vasodilation and therefore contribute to coronary regulation, without directly altering myocardial performance.
Yanagisawa et al. (1988) studied Coronary vascular smooth muscle function. Synthetic atrial natriuretic factor (ANF) was evaluated on Perfusion pressure and relaxation of coronary strips. Synthetic atrial natriuretic factor (3-300 nM) decreased perfusion pressure and relaxed isolated cat coronary arteries in a concentration-dependent manner without directly altering myocardial performance.