What question did this study set out to answer?

This research aims to explore the use of beta-lactam therapeutic drug monitoring (TDM) in outpatient care to optimize dosing and reduce toxicity.

May 27, 2026Open Access

Early Experience with Beta-Lactam Therapeutic Drug Monitoring in an Outpatient Parenteral Antimicrobial Therapy (OPAT) Program

Key Points

This research aims to explore the use of beta-lactam therapeutic drug monitoring (TDM) in outpatient care to optimize dosing and reduce toxicity.
Descriptive analysis of beta-lactam TDM implementation in an outpatient parenteral antimicrobial therapy program.
Cases of selected patients were reviewed to illustrate the feasibility of TDM.
Beta-lactam TDM informed dose adjustments leading to improved therapeutic outcomes.
Emerging lessons from the cases indicated successful toxicity mitigation strategies.

Abstract

Abstract We describe early experience with beta-lactam therapeutic drug monitoring (TDM) in a high-volume outpatient parenteral antimicrobial therapy (OPAT) program. In selected patients, TDM informed dose optimization and toxicity mitigation. Illustrative cases highlight feasibility and emerging lessons supporting beta-lactam TDM in outpatient care.

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