This comprehensive review summarizes pre-clinical and clinical data on the effectiveness of pulsed-field ablation for treating monomorphic ventricular tachycardia compared to thermal ablation modalities.
Does catheter-based irreversible electroporation (pulsed-field ablation) effectively treat monomorphic ventricular tachycardia compared to thermal ablation modalities?
This comprehensive review outlines the current pre-clinical and clinical evidence, as well as potential advantages and pitfalls, of using pulsed-field ablation for the treatment of ventricular tachycardia.
The use of catheter-based irreversible electroporation in clinical cardiac laboratories, termed pulsed-field ablation (PFA), is gaining international momentum among cardiac electrophysiology proceduralists for the non-thermal management of both atrial and ventricular tachyrhythmogenic substrates. One area of potential application for PFA is in the mitigation of ventricular tachycardia (VT) risk in the setting of ischemia-mediated myocardial fibrosis, as evidenced by recently published clinical case reports. The efficacy of tissue electroporation has been documented in other branches of science and medicine; however, ventricular PFA's potential advantages and pitfalls are less understood. This comprehensive review will briefly summarize the pathophysiological mechanisms underlying VT and then summarize the pre-clinical and adult clinical data published to date on PFA's effectiveness in treating monomorphic VT. These data will be contrasted with the effectiveness ascribed to thermal cardiac ablation modalities to treat VT, namely radiofrequency energy and liquid nitrogen-based cryoablation.
Repp et al. (Wed,) conducted a review in Ventricular tachycardia. Pulsed-field ablation (PFA) vs. Thermal cardiac ablation (radiofrequency and cryoablation) was evaluated. This comprehensive review summarizes pre-clinical and clinical data on the effectiveness of pulsed-field ablation for treating monomorphic ventricular tachycardia compared to thermal ablation modalities.