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January 1, 1993European Journal of Cardio-Thoracic Surgery33 citations

Atrial fibrillation after coronary artery bypass grafting: a comparison of cardioplegia versus intermittent aortic cross-clamping

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JBJohn M. ButlerNational Institute of Standards and TechnologyJCJames J.H. ChongInterventional CardiologyGRGraeme RockerQueen Elizabeth II Health Sciences Centre

Key Result

Cold potassium cardioplegia with hypothermia showed no significant difference in postoperative atrial fibrillation/flutter compared to intermittent aortic cross-clamping (25.6% vs 19.3%, P>0.25).

Study Design

Type

Cohort (n=170)

Structured PICO

Does cold potassium cardioplegia compared to intermittent aortic cross-clamping reduce postoperative atrial fibrillation/flutter in patients undergoing coronary artery bypass grafting?

P
Population
170 patients undergoing coronary artery bypass grafting
I
Intervention
Cold potassium cardioplegia combined with topical hypothermia and systemic cooling to 28 degrees C
C
Comparator
Intermittent aortic cross-clamping with a systemic temperature of 32 degrees C
O
Outcome
Incidence of clinically important postoperative atrial fibrillation/flutterhard clinical

The choice of myocardial protection technique (cardioplegia vs. intermittent cross-clamping) does not significantly affect the incidence of postoperative atrial fibrillation after CABG, whereas older age is a significant risk factor.

Main Result

Absolute Event Rate: 25.6% vs 19.3%

p-value: p=> 0.25

Abstract

Supraventricular tachyarrhythmias following coronary artery bypass grafting are a common cause of postoperative morbidity, with a reported incidence of 10-40%. Two techniques of myocardial protection were assessed to determine their influence on the occurrence of postoperative supraventricular tachyarrhythmias. Group I (n = 82) received cold potassium cardioplegia combined with topical hypothermia and systemic cooling to 28 degrees C. Group II (n = 88) were protected by intermittent aortic cross-clamping with a systemic temperature of 32 degrees C. The overall incidence of atrial fibrillation/flutter was 22.3%. No significant difference was detected in the incidence of clinically important atrial fibrillation/flutter between the two groups 21/82 (25.6%) in group I versus 17/88 (19.3%) in group II, P > 0.25. There was a positive association with age: in patients over 60 years the incidence of arrhythmias (31.8%) was significantly greater than in those less than 60 years (12.9%), P < 0.01. Sex, cardiopulmonary bypass times, aortic cross-clamp times, number of coronary grafts, end-operative creatine kinase myocardial band isoenzyme, right coronary endarterectomy and perioperative myocardial infarction had no association with the occurrence of postoperative atrial tachyarrhythmias.

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Cite This Study

Butler et al. (1993) conducted a cohort in Coronary artery bypass grafting (n=170). Cold potassium cardioplegia with topical hypothermia and systemic cooling vs. Intermittent aortic cross-clamping with systemic temperature of 32 degrees C was evaluated on Clinically important atrial fibrillation/flutter (p=> 0.25). Cold potassium cardioplegia with hypothermia showed no significant difference in postoperative atrial fibrillation/flutter compared to intermittent aortic cross-clamping (25.6% vs 19.3%, P>0.25).

synapsesocial.com/papers/6a17151825571367076bf883https://doi.org/10.1016/1010-7940(93)90143-y
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Aortic Cross-Clamping Time on Development of Postoperative Atrial Fibrillation in Isolated CABG: A Single-Center Prospective Clinical Study2023 · 2 citations
  2. 2Arrhythmias after coronary bypass surgery.1984 · 88 citations
  3. 3Myocardial Reperfusion after Coronary Bypass Surgery:<i>Suture of Only Distal or All Anastomoses with the Aorta Cross-clamped?</i>1995 · 5 citations
  4. 4Rhythm Disturbances after Blood and Crystalloid Cardioplegia in Coronary Artery Bypass Grafting1995 · 7 citations
  5. 5POST-OPERATIVE ATRIAL FIBRILLATION; INCIDENCE AFTER CORONARY ARTERY BYPASS GRAFT SURGERY2015