Electrocardiographic left atrial abnormality (PTFV1 >40 ms.mm) was significantly associated with ischemic stroke (OR 2.32; 95% CI 1.29-4.18), independent of echocardiographic left atrial diameter.
Case-Control (n=341)
Is electrocardiographic left atrial abnormality (ECG-LAA) associated with an increased risk of ischemic stroke?
Electrocardiographic left atrial abnormality, specifically PTFV1 >40 ms.mm, is independently associated with ischemic stroke and provides additive prognostic value to echocardiography, particularly in patients with increased left ventricular mass.
Effect estimate: OR 2.32 (95% CI 1.29-4.18)
BACKGROUND AND PURPOSE: We evaluated the association between electrocardiographic left atrial abnormality (ECG-LAA) and ischemic stroke, especially whether ECG-LAA provides additional prognostic information to that provided by echocardiography. METHODS: A population-based, case-control study included 146 patients with first ischemic stroke and 195 age-, gender-, and race/ethnicity-matched community control subjects. ECG-LAA was defined as either P-wave duration >120 ms or P-terminal force in precordial lead V1 (PTFV1) >40 ms.mm. RESULTS: PTFV1 >40 ms.mm was associated with ischemic stroke after adjustment for other stroke risk factors (odds ratio OR, 2.32; 95% CI, 1.29 to 4.18). The association remained significant after adding echocardiographic left atrial diameter to the model (OR, 2.31; 95% CI, 1.28 to 4.17). PTFV1 was independently associated with stroke in patients in the upper half of echocardiographically determined left ventricular mass (adjusted OR, 4.5; 95% CI, 2.20 to 9.15) but not in those in the lower half (OR, 0.58; 95% CI, 0.20 to 1.65; P=0.0008). CONCLUSIONS: ECG-LAA can supplement 2D echocardiography in assessing the risk of ischemic stroke, especially in subjects with increased left ventricular mass.
Kohsaka et al. (Fri,) conducted a case-control in Ischemic stroke (n=341). Electrocardiographic left atrial abnormality (PTFV1 >40 ms.mm) vs. Community control subjects was evaluated on Ischemic stroke (OR 2.32, 95% CI 1.29-4.18). Electrocardiographic left atrial abnormality (PTFV1 >40 ms.mm) was significantly associated with ischemic stroke (OR 2.32; 95% CI 1.29-4.18), independent of echocardiographic left atrial diameter.
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