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May 30, 2026Journal of Clinical Oncology0 citations

Oncolytic Vaccinia Virus Expressing Tethered IL-12/IL-2 Fusion Cytokine Shows Antitumor Effects

Associated antitumor effects of oncoytic vaccinia virus expressing a tethered IL-12/IL-2 fusion cytokine.

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Authors

PMPingpo MingJYJunjie YeLCLingjuan Chen

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Overview

Randomized trial demonstrates superior antitumor activity in murine tumors, indicating potential for immunotherapy enhancement.

Key Points

  • This study aims to investigate the antitumor efficacy of an oncolytic vaccinia virus expressing a tethered IL-12/IL-2 fusion cytokine compared to single-cytokine viruses.
  • Engineered two oncolytic vaccinia viruses: one with IL-12 and one with a tethered IL-12/IL-2 fusion.
  • Confirmed gene expression via RT-qPCR and validated membrane association using flow cytometry.
  • Evaluated antitumor efficacy in multiple murine tumor models and assessed immune response mechanisms.
  • vvDD-scIL-12-R-IL-2-RG significantly outperformed single-cytokine viruses in tumor regression.
  • In late-stage MC38 model, 85% of animals achieved complete tumor regression without systemic toxicity.
  • Treatment elevated intratumoral Th1 chemokines and IFN-γ, enhancing CD8⁺ T cell infiltration and conferring tumor specificity.
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Cite This Study

Ming et al. (2026) studied this question.

synapsesocial.com/papers/6a1a7f410307b785094319edhttps://doi.org/10.1200/jco.2026.44.16_suppl.e14557
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