Both resistance and aerobic training reduced mean arterial pressure (~20 and ~8 mmHg) and improved baroreflex sensitivity in ovariectomized hypertensive rats versus sedentary controls.
Does resistance or aerobic training reduce arterial pressure and improve autonomic control and oxidative stress in ovariectomized spontaneously hypertensive rats?
Both resistance and aerobic training effectively decrease arterial pressure and attenuate autonomic dysfunction and cardiac oxidative stress in a rat model of menopause and hypertension.
We investigated whether resistance training (RT) vs. aerobic training (AT) differentially impacts on arterial pressure and related mechanisms in ovariectomized spontaneously hypertensive rats (SHRs). Female SHRs were ovariectomized and assigned to one of the following groups: sedentary, AT, or RT; sham sedentary SHR were used as control group. AT was performed on a treadmill, whereas RT was performed on a vertical ladder. Both exercise protocols were performed for 8 wk, 5 days/wk. Arterial pressure, baroreflex sensitivity, autonomic modulation, and cardiac oxidative stress parameters (lipid peroxidation, protein oxidation, redox balance, NADPH oxidase, and antioxidant enzymes activities) were analyzed. Ovariectomy increased mean arterial pressure (∼9 mmHg), sympathetic modulation (∼40%), and oxidative stress in sedentary rats. Both RT and AT reduced mean arterial pressure (∼20 and ∼8 mmHg, respectively) and improved baroreflex sensitivity compared with sedentary ovariectomized rats. However, RT-induced arterial pressure decrease was significantly less pronounced than AT. Lipid peroxidation and protein oxidation were decreased while antioxidant enzymes were increased in both trained groups vs. sedentaries. The reduced gluthatione was higher after AT vs. other groups, whereas oxidized gluthatione was lower after RT vs. AT. Moreover, sympathetic and parasympathetic modulations were highly correlated with cardiac oxidative stress parameters. In conclusion, both RT and AT can decrease arterial pressure in a model of hypertension and menopause; although, at different magnitudes this decrease was related to attenuated autonomic dysfunction in association with cardiac oxidative stress improvement in both exercise protocols.
Palma et al. (Fri,) conducted a other in Hypertension and menopause (animal model). Resistance training or aerobic training vs. Sedentary ovariectomized rats and sham sedentary rats was evaluated on Mean arterial pressure. Both resistance and aerobic training reduced mean arterial pressure (~20 and ~8 mmHg) and improved baroreflex sensitivity in ovariectomized hypertensive rats versus sedentary controls.