Rheumatoid arthritis was associated with a 43.9% incidence of fatal or nonfatal cardiovascular events compared to 37.5% in osteoarthritis over 8 years, which was not statistically significant.
Cohort (n=201)
No
Does rheumatoid arthritis increase the risk of fatal or non-fatal cardiovascular diseases compared to osteoarthritis in patients without previous cardiovascular disease?
In patients without prior cardiovascular disease, rheumatoid arthritis is associated with a high incidence of fatal and non-fatal cardiovascular events, predominantly chronic heart failure, underscoring the need for strict inflammation control.
Absolute Event Rate: 43.9% vs 37.5%
p-value: p=0.381
Abstract Background Patients with rheumatoid arthritis have significant cardiovascular mortality and morbidity. Objective To investigate the effects of chronic inflammation in rheumatoid arthritis on cardiovascular morbidity association with cardiovascular risk factors risk factors. Mortality report is secondary just to show trends without sufficient statistical power as it is accidental endpoint. Methods A total of 201 individuals without previous cardiovascular disease, 124 with rheumatoid arthritis (investigation group) and 77 with osteoarthritis (control group), were included in the study and followed up for an average of 8 years to assess the development of fatal or non-fatal cardiovascular diseases. The incidence and prevalence of cardiovascular risk factors were also investigated. Results The total incidence of one or more fatal or nonfatal cardiovascular events was 43.9% in the investigation group and 37.5% in the control group. Of these patients, 31.7% and 30.9% survived cardiovascular events in the investigation and control groups, respectively. The most common cardiovascular disease among participants who completed the study and those who died during the study was chronic heart failure. The results of the subgroup analysis showed that strict inflammation control plays a central role in lowering cardiovascular risk.. Conclusion A multidisciplinary approach to these patients is of paramount importance, especially with the cooperation of immunologists and cardiologists for early detection, prevention, and management of cardiovascular risks and diseases.
Bedeković et al. (Mon,) conducted a cohort in Rheumatoid arthritis (n=201). Rheumatoid arthritis vs. Osteoarthritis was evaluated on Total incidence of one or more fatal or nonfatal cardiovascular events (p=0.381). Rheumatoid arthritis was associated with a 43.9% incidence of fatal or nonfatal cardiovascular events compared to 37.5% in osteoarthritis over 8 years, which was not statistically significant.
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