The paper proposes two models for thin filament assembly in cardiac and skeletal muscle based on in vitro observations, setting the stage for future in vivo testing.
The assembly and functional characteristics of many contractile proteins are different in skeletal and cardiac muscle. Two models for thin filament assembly are consistent with observations from recent studies focused on determining the functional significance of actin filament capping in primary cultures of embryonic chick myogenic cells and cardiac myocytes. Future experiments will test the validity of the proposed models for in vivo embryonic development.
Carol C. Gregorio (Wed,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: