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We read with interest the meta-analysis by Mezuk et al. (1) on the bidirectional relationship between diabetes and depression. In their report, the authors examined whether having depression increases risk of type 2 diabetes and the inverse relationship, namely, whether having type 2 diabetes increases risk of depression. The authors concluded that depression was associated with a 60% increased risk of developing type 2 diabetes but that there was only a modest (15%) increased risk of depression in individuals with type 2 diabetes. While we welcome this report, we would argue that there are a number of important methodological and conceptual issues that …
Nouwen et al. (Thu,) studied this question.