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May 31, 2026Indian Journal of Psychiatry0 citationsOpen Access

Electrocardiographic Changes in Chronic Schizophrenic Patients

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SNS. Haque NizamieSSShridhar Sharma

Key Points

  • The study aims to assess electrocardiographic changes in chronic schizophrenic patients receiving trifluoperazine.
  • Compared ECGs of 43 experimental and 60 control patients
  • Administered 4 mg of trifluoperazine daily by IM route for five days
  • Conducted three 12-lead ECGs for each patient
  • Significant ECG changes observed in the experimental group, particularly in older patients
  • More pronounced changes were noted in patients over 45 years
  • Statistical analysis confirmed significant variations in ECG variables

Abstract

The electrocardiograms were compared in two groups of schizophrenic patients (Experimental group N=43, Control group N=60). The selected cases were given 4 mg of Trifluoperazine daily by IM route for five days. A 12 lead ECG was taken thrice in each case. A statistical analysis of the data showed definite changes in many of the ECG variables. Comparatively more changes were noticed in the experimental group and in patients beyond the age of 45 years.

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Cite This Study

Nizamie et al. (1988) studied this question.

synapsesocial.com/papers/6a1bd0525783ba022b6fc1c1https://doi.org/10.4103/ijopsy_1988302_183
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