Therapeutic Approaches to Yakrit-Pleeha Roga in Bhaishajya Ratnavali: A Review

Liver diseases constitute a major global health burden, contributing significantly to morbidity and mortality. The spectrum of liver diseases ranges from simple steatosis to cirrhosis and is influenced by factors such as alcohol consumption, metabolic disturbances, and lifestyle changes. Contemporary research indicates a significant overlap between alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), with shared mechanisms including oxidative stress, inflammation, and metabolic dysfunction. In Ayurveda, hepatosplenic disorders are described under Yakrit-Pleeha Roga and are often associated with conditions such as Pandu, Kamala, and Udara Roga. The present study aims to correlate modern hepatic disorders with Ayurvedic concepts and to systematically compile formulations indicated in Yakrit-Pleeha Roga from Bhaishajya Ratnavali. The pathogenesis involves Mandagni, Ama formation, and Srotorodha, leading to progressive tissue damage. Management is based on Samprapti-vighatana, employing Deepana-Pachana, Srotoshodhana, Lekhana, and Shothahara therapies. The study highlights the therapeutic relevance of classical formulations in the management of liver disorders.