Statins were associated with less increase in annual peak valve velocity in observational studies, but randomized controlled trials showed no significant benefit on aortic stenosis progression.
Meta-Analysis
Does statins therapy improve peak aortic valve velocity, peak valve gradient, mean valve gradient, aortic valve area and aortic calcification in patients with aortic stenosis?
Meta-analysis of RCTs demonstrates that statin therapy does not halt the progression of aortic stenosis, despite conflicting results from observational studies.
p-value: p=0.003
Aortic stenosis has been shown to share the same risk factors as atherosclerosis which suggested a potential benefit from statins therapy. Fourteen studies which provided the effect of statins treatment on aortic stenosis (AS) were meta-analyzed, including 5 randomized controlled trials (RCTs) and 9 observational studies. In the RCTs, statins did not have any influence on peak aortic valve velocity, peak valve gradient, mean valve gradient, aortic valve area and aortic calcification compared to controls. In the observational studies, the peak valve velocity, peak gradient and aortic valve area showed less progression in the statins group compared to controls. This article describes data related article title "The effect of statins on valve function and calcification in aortic stenosis: a meta-analysis" (Zhao et al., 2016) 1.
Zhao et al. (Sat,) conducted a meta-analysis in Aortic stenosis. Statins vs. Controls was evaluated on Annual peak valve velocity (p=0.003). Statins were associated with less increase in annual peak valve velocity in observational studies, but randomized controlled trials showed no significant benefit on aortic stenosis progression.
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