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A five-month oral course of the repurposed drug ketotifen re-acidifies lysosomes in aged microglia and macrophages, restoring microglial homeostasis, preserving synaptic integrity, and mitigating memory decline in aged male mice. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Targeting lysosomal acidification to restore microglial homeostasis and mitigate memory decline during male brain ageing

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