MRI is a histologically validated technique that accurately identifies key carotid plaque features, permitting prospective testing of the vulnerable plaque hypothesis.
Does MRI accurately identify and classify high-risk atherosclerotic carotid plaque features compared to traditional luminal stenosis criteria?
MRI serves as a histologically validated imaging tool for the in vivo characterization of high-risk, vulnerable carotid plaques, moving beyond simple luminal stenosis criteria for stroke risk assessment.
Stroke is a leading cause of mortality and long-term morbidity. As a means for stroke prevention, an estimated 99,000 carotid endarterectomy procedures were performed in the USA in 2006. Traditionally, the degree of luminal stenosis has been used as a marker of the stage of atherosclerosis and as an indication for surgical intervention. However, prospective clinical trials have shown that the majority of patients with a history of recent transient ischemic attack or stroke have mild-to-moderate carotid stenosis. Using stenosis criteria, many of these symptomatic individuals would be considered to have early-stage carotid atherosclerosis. It is evident that improved criteria are needed for identifying the high-risk carotid plaque across a range of stenoses. Histological studies have led to the hypothesis that plaques with larger lipid-rich necrotic cores, thin fibrous cap rupture, intraplaque hemorrhage, plaque neovasculature and vessel wall inflammation are characteristics of the high-risk, 'vulnerable plaque'. Despite the widespread consensus on the importance of these plaque features, testing the vulnerable plaque hypothesis in prospective clinical studies has been hindered by the lack of reliable imaging tools for in vivo plaque characterization. MRI has been shown to accurately identify key carotid plaque features, including the fibrous cap, lipid-rich necrotic core, intraplaque hemorrhage, neovasculature and vascular wall inflammation. Thus, MRI is a histologically validated technique that will permit prospective testing of the vulnerable plaque hypothesis. This article will provide a summary of the histological validation of carotid MRI, and highlight its application in prospective clinical studies aimed at early identification of the high-risk atherosclerotic carotid plaque.
Hatsukami et al. (Mon,) conducted a review in Carotid atherosclerosis. MRI was evaluated. MRI is a histologically validated technique that accurately identifies key carotid plaque features, permitting prospective testing of the vulnerable plaque hypothesis.