Among 10,000 subjects, baseline nonspecific ST segment or T wave abnormalities (n=637) were associated with a significantly higher risk of developing new-onset atrial fibrillation or flutter.
Cohort (n=10,000)
Does the presence of nonspecific ST-segment and T-wave abnormalities (NSSTTA) predict the development of atrial fibrillation or flutter in hypertensive patients?
Nonspecific ST-segment and T-wave abnormalities on a standard 12-lead ECG are associated with an increased long-term risk of developing atrial fibrillation or flutter in hypertensive patients.
Objective: The association between nonspecific ST segment or T wave abnormalities (NSSTTA) and long-term risk of atrial arrhythmia was not well evaluated. We tested a hypothesis that nonspecific ST segment or T wave abnormalities (NSSTTA) might be associated with future risk of atrial fibrillation (AF) or flutter (AFL). Design and method: The study population comprised of 10,000 subjects who underwent medical checkups in 10 years. and at least one or more follow-up electrocardiography (ECG) were available. The patients were divided into two groups according to the presence (n=637) or absence of NSSTTA in the baseline ECG. NSSTTA was defined as manually interpreted ST segment or T wave abnormalities corresponding to the Minnesota code. The primary outcome of the current study was ECG-documented AF or AFL. Results: The patients with NSSTTA were characterized by elder age, fewer male subjects. During the follow-up period, new-onset AF or AFL were documented in 334 subjects. The incidence of AF or AFL at the 5 years of follow-up was higher in patients with NSSTTA compared to those without NSSTTA. The patients with NSSTTA were at significant higher risk of developing AF or AFL in both univariable and multivariable analysis. Especially patients with major NSTTA and NSTTA in multiple regions were at higher risk of AF Conclusions: NSSTTA in the 12-lead ECG is associated with higher risk of future AF or AFL in hypertension.
KOH et al. (Fri,) conducted a cohort in Hypertension (n=10,000). Nonspecific ST segment or T wave abnormalities (NSSTTA) vs. Absence of NSSTTA was evaluated on ECG-documented atrial fibrillation or flutter. Among 10,000 subjects, baseline nonspecific ST segment or T wave abnormalities (n=637) were associated with a significantly higher risk of developing new-onset atrial fibrillation or flutter.