What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Hypertension (n=853). Intervention: Plasma adrenomedullin (ADM) concentration. Primary outcome: Association between pulse wave velocity (PWV) and ADM (beta-coefficient 0.11, 95% CI 0.026-0.19, p=0.01).

What does this research mean for the field?

Plasma adrenomedullin concentration is independently and positively associated with pulse wave velocity in hypertensive patients, indicating its potential as a marker for advanced arterial stiffness. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 3, 2026

Plasma Adrenomedullin Is Independently Associated With Pulse Wave Velocity

Key Result

Plasma adrenomedullin concentration was independently and positively associated with pulse wave velocity (beta-coefficient 0.11; 95% CI 0.026-0.19; p=0.01).

Key Points

This study aims to explore the relationship between pulse wave velocity (PWV) and adrenomedullin (ADM) in hypertensive patients.
Analyzed plasma ADM concentration in 853 hypertensive patients.
Performed carotid-femoral PWV measurements using the SphygmoCor XCEL device.
Conducted Spearman correlation and multivariable linear regression to evaluate associations.
Significant positive correlation between PWV and ADM (r = 0.09, p = 0.01).
Multivariable regression revealed a positive association (beta = 0.11, 95% CI: 0.026-0.19, p = 0.01).
Plasma ADM concentration may indicate advanced arterial stiffness assessed by PWV.

Study Design

Type

Cross-Sectional (n=853)

Structured PICO

Is plasma adrenomedullin concentration associated with pulse wave velocity in hypertensive patients?

Population

853 hypertensive patients (mean age 54.5 years, 54.2% female) assessed for the relationship between pulse wave velocity and plasma adrenomedullin.

Outcome

Association between pulse wave velocity (PWV) and plasma adrenomedullin (ADM) concentrationsurrogate

Plasma adrenomedullin concentration is independently associated with pulse wave velocity, suggesting it may serve as a marker of advanced arterial stiffness in hypertensive patients.

Main Result

Effect estimate: beta-coefficient 0.11 (95% CI 0.026-0.19)

p-value: p=0.01

Abstract

Objective: The aim of the study was to investigate the relationship between pulse wave velocity (PWV) and adrenomedullin (ADM) in hypertensive patients. Design and method: We analyzed plasma ADM concentration in 853 patients. Carotid-femoral PWV was performed using the SphygmoCor XCEL device, AtCor Medical. Spearman correlation analysis and multivariable linear regression were performed to evaluate the association between PWV and ADM. Results: The mean age of the study population was 54.5± 13.5 years. Men constituted 45.8% of the group. Participants suffered from: dyslipidemia (76.8%), diabetes (41.3%), coronary artery disease (11.8%), and cerebrovascular disease (6.2%). The mean value of PWV was 10.2 ± 2.3 m/s. The average blood pressure of the 24-hour ambulatory monitoring was 129 ± 13 mm Hg/77 ± 9 mm Hg. A significant, positive link between PWV and ADM was observed (r = 0.09, p = 0.01). Multivariable regression model, adjusted for sex, age, BMI, diabetes, systolic blood pressure, and smoking status, revealed a positive association between PWV and ADM (beta- coefficient: 0.11, 95% confidence interval: 0.026-0.19, p = 0.01). Conclusions: ADM was independently associated with PWV. These results suggest that plasma AMD concentration may serve as an additional marker of advanced arterial stiffness estimated by PWV.

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