Objective: Cardiometabolic diseases, including hypertension are a highly prevalent condition in older adults. Moreover, blood pressure variability strongly contributes to the appearance of cognitive deficit. The aim of our study was to evaluate the relation between cardiometabolic parameters and cognitive functions and profile in hospitalised geriatric patients.Design and method: We included consecutive hospitalized patients aged >65 years. The symptoms of dementia were evaluated using Addenbrooke's Cognitive Examination-III (ACE-III) with assessment of memory, fluence, attention, language, and visuospatial abilities. Cardiovascular risk factors were assessed, physical examination with blood pressure measurements and body mass index (BMI) and laboratory tests including haemoglobin, LDL cholesterol (LDL), glucose, C-reactive protein (CRP), N-terminal pro–B-type natriuretic peptide (NT-pro BNP) and creatinine serum concentrations were performed. Results: We included 372 patients (262 females and 110 males, median age 82 76-87 years). Patients with dementia (84% had hypertension) when comparing to patients without dementia (86.5% had hypertension) had significantly lower BMI, systolic and diastolic blood pressure (25.7 kg/m2 23.3-28.9 vs 27.6 kg/m2 24.1-30.8, p<0.008, 128mmHg 112-140 vs 130mmHg 120-145, p=0.018 and 70mmHg 62-78 vs 75mmHg 66-82, p=0.002, respectively) but higher creatinine and NT-pro BNP concentrations 0.95 mg/dl 0.80-1.20 vs 0.88 mg/dl 0.73-1.03, p=0.011 and 420 pg/ml 220 – 963 vs 258 pg/ml 134-477, p<0.001, respectively. The multivariable analysis showed that only age (-0.012 -0.016 - -0.007) and diastolic blood pressure (0.006 0.000 -0.011), but not any other cardiometabolic parameters were independently related to total cognitive function. The multivariable analysis showed that only age (-0.017 -0.026 - -0.009) and mean 24-hours diastolic blood pressure (0.050 0.004 - 0.097) were independently related to memory and age (-0.023 -0.032 - -0.014), diastolic blood pressure (0.013 0.002 - 0.024), and mean systolic blood pressure at night (-0.007 -0.012 - -0.001), but no biochemical cardiometabolic parameters were independently related to any domains of cognitive function. Conclusions: Age, diastolic blood pressure and systolic blood pressure at night are associated with the profile of cognitive functions.
Kupisz-Urbańska et al. (Fri,) studied this question.