Genetically altered murine models provide valuable tools for understanding the complex mechanisms of atrial fibrillation and assessing novel therapeutic interventions.
Genetically modified murine models provide valuable tools for dissecting the polygenic and multi-factorial molecular mechanisms underlying atrial fibrillation.
Understanding the mechanism of re-entrant arrhythmias in the past 30 years has allowed the development of almost curative therapies for many rhythm disturbances. The complex, polymorphic arrhythmias of atrial fibrillation (AF) and sudden death are, unfortunately, not yet well understood, and hence still in need of adequate therapy. AF contributes markedly to morbidity and mortality in aging Western populations. In the past decade, many genetically altered murine models have been described and characterized. Here, we review genetically altered murine models of AF; powerful tools that will enable a better understanding of the mechanisms of AF and the assessment of novel therapeutic interventions.
Riley et al. (Sun,) conducted a review in Atrial fibrillation. Genetically altered murine models was evaluated. Genetically altered murine models provide valuable tools for understanding the complex mechanisms of atrial fibrillation and assessing novel therapeutic interventions.
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