July 1, 2000Open Access

Pseudomonas aeruginosa Cell-to-Cell Signaling Is Required for Virulence in a Model of Acute Pulmonary Infection

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Abstract

ABSTRACT Cell-to-cell signaling controls many virulence genes in Pseudomonas aeruginosa . We tested the virulence of las and rhl quorum-sensing mutants in neonatal mice. A lasI rhlI double mutant was nearly avirulent, and the respective single mutant strains were reduced in virulence compared with the wild-type strain. Quorum sensing plays a role in P. aeruginosa pneumonia in neonatal mice.

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Pearson et al. (Sat,) studied this question.

synapsesocial.com/papers/6a202cca5a40e2199cd8d2f9 https://doi.org/https://doi.org/10.1128/iai.68.7.4331-4334.2000

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