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In SV40 infected grivet monkey, rhesus monkey, primary fetal human, SV40 transformed fetal human and primary newborn Syrian hamster kidney tissue cultures viral antigen is found in the nucleus. Because of aggregation of antigen around what appears to be altered nucleoli in all 4 tissues it is suggested that viral synthesis and assembly may occur in the nucleolus. In the 4 tissues studied there is an inverse correlation between proportion of cells exhibiting specific nuclear fluorescence, brilliance of fluorescence and ease of induction of transformation in vitro.
Levinthal et al. (Fri,) studied this question.