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INTRODUCTION: m), the gene encoding the estrogen receptor, can drive resistance to AI; their detection in circulating tumor DNA from liquid biopsies may be used to guide treatment. AREAS COVERED: m coverage, sensitivity, and specificity. EXPERT OPINION: m with differing sensitivity and specificity depending on the assay and amount of input DNA. Assay selection will vary depending on analytical performance, turnaround times, lab infrastructure and expertise, healthcare setting, and regional variation in market costs.
Yarunin et al. (Tue,) studied this question.