The Sampson equation was most accurate for calculating LDL-C in the fasting state (67% with residual error <0.13 mmol/L vs 57% for Friedewald), while extended-Martin-Hopkins was best post-prandial.
Observational (n=7,006)
Do the Sampson and extended-Martin-Hopkins equations improve the accuracy of LDL-C calculation compared to the Friedewald equation in fasting and non-fasting hypertriglyceridemic patients?
Both Sampson and extended-Martin-Hopkins equations outperform the Friedewald equation for calculating LDL-C when triglycerides are <4.52 mmol/L, with Sampson performing best in fasting patients and extended-Martin-Hopkins in non-fasting patients.
Absolute Event Rate: 67% vs 57%
OBJECTIVES: Low-density lipoprotein cholesterol (LDL-C) concentration was calculated for many years using the Friedewald equation, but those from Sampson and extended-Martin-Hopkins perform differently. Their accuracy in fasting hypertriglyceridemia and non-fasting state were compared and the clinical impact of implementing these equations on risk classification and on the setting of lipid treatment goals was assessed. METHODS: Seven thousand six standard lipid profiles and LDL-C concentrations measured after ultracentrifugation (uLDL-C) were retrospectively included. uLDL-C were compared to calculated LDL-C in terms of correlation, root mean square error, residual error, mean absolute deviations and cardiovascular stratification. RESULTS: In fasting state (n=5,826), Sampson equation was the most accurate, exhibited the highest percentage of residual error lower than 0.13 mmol/L (67 vs. 57 % and 63 % using Friedewald, or extended-Martin-Hopkins equations respectively) and the lowest misclassification rate. However, the superiority of this equation was less pronounced when triglyceride concentration (TG) 4.52 mmol/L. When TG<4.52 mmol/L both Sampson and Martin-Hopkins equations performed better than Friedewald. The switch to one or the other should take in account their limitations, their ease of implementation into the lab software and the proportion of non-fasting patients.
Vasse et al. (Thu,) conducted a observational in Hypertriglyceridemia (n=7,006). Sampson equation vs. Friedewald equation was evaluated on Percentage of residual error lower than 0.13 mmol/L in the fasting state. The Sampson equation was most accurate for calculating LDL-C in the fasting state (67% with residual error <0.13 mmol/L vs 57% for Friedewald), while extended-Martin-Hopkins was best post-prandial.