Renal denervation consistently improved cardiac and sympathetic baroreflex sensitivity in both hypertensive rats and humans, even when systolic blood pressure did not decrease.
Does renal denervation improve blood pressure, sympathetic nerve activity, and baroreflex function in hypertensive rats and humans?
Renal denervation consistently improves baroreflex sensitivity in both hypertensive rats and humans, even in the absence of significant blood pressure reduction.
p-value: p=<0.05
Renal denervation has shown promise in the treatment of resistant hypertension, although the mechanisms underlying the blood pressure (BP) reduction remain unclear. In a translational study of spontaneously hypertensive rats (n=7, surgical denervation) and resistant hypertensive human patients (n=8; 5 men, 33-71 years), we examined the relationship among changes in BP, sympathetic nerve activity, and cardiac and sympathetic baroreflex function after renal denervation. In humans, mean systolic BP (SBP; sphygmomanometry) and muscle sympathetic nerve activity (microneurography) were unchanged at 1 and 6 months after renal denervation (P90% reduction in renal norepinephrine content) denervation. We conclude that (1) renal denervation improves BP in some patients, but sympathetic activity does not always change in parallel, and (2) baroreflex sensitivity is consistently improved in animals and humans, even when SBP has not decreased. Determining procedural success will be crucial in advancing this treatment modality.
Hart et al. (Tue,) conducted a other in Resistant hypertension (n=15). Renal denervation was evaluated on Changes in blood pressure, sympathetic nerve activity, and cardiac and sympathetic baroreflex function (p=<0.05). Renal denervation consistently improved cardiac and sympathetic baroreflex sensitivity in both hypertensive rats and humans, even when systolic blood pressure did not decrease.