Neurohormonal antagonists are supported by small studies for treating chemotherapy-induced cardiomyopathy, but large trials are needed to establish specific guidelines.
Management of chemotherapy-induced cardiomyopathy currently relies on standard heart failure guidelines and close collaboration between cardiologists and oncologists.
Chemotherapy related cardiac dysfunction (CRCD) is a serious complication of anticancer therapy. CRCD can be classified into two types. Type I CRCD is exemplified by anthracyline- induced cardiac dysfunction and type II CRCD is exemplified by trastuzumab- induced cardiac dysfunction. The mechanism of cardiac toxicity in both types is not well defined. Certain risk factors may play a role in developing the cardiac injury, most importantly, the cumulative dose when dealing with anthracycline induced cardiotoxicity. Establishing an early diagnosis and initiating early treatment may be an important step in preventing irreversible cardiac injury especially in type I CRCD. Currently there are no guidelines developed specifically for the treatment of chemotherapy induced cardiomyopathy (CIC), however a few small studies support the use of neurohormonal antagonists in the treatment and prevention of CIC. Large multi- centers trials are needed to establish guidelines for CIC. Until then, we advocate following the American College of Cardiology/ American Heart Association (ACC/AHA) and Heart Failure Society of America (HFSA) guidelines. Additionally, a close collaboration between the patient's cardiologist and oncologist is strongly recommended in order to establish a long term plan for the patient.
Saidi et al. (Tue,) conducted a review in Chemotherapy Induced Cardiomyopathy. Neurohormonal antagonists was evaluated. Neurohormonal antagonists are supported by small studies for treating chemotherapy-induced cardiomyopathy, but large trials are needed to establish specific guidelines.