Abstract Background Cisplatin (CIS), a broadly used chemotherapy, is linked with hepatotoxicity caused by oxidative injury and inflammation. The current study explores the hepato-protective effects of diallyl disulfide (DDS), a natural organosulfur compound, against CIS-induced hepatotoxicity. Method In this investigation, rats were allocated to control, DDS (10 mg/kg), CIS (7 mg/kg), and DDS + CIS groups. Results DDS reduces liver damage caused by CIS, as shown by lowering serum ALT and AST. Histopathological evaluations revealed significant liver tissue architecture preservation in DDS-treated groups. DDS treatment ameliorates hepatic oxidative stress induced by CIS and significantly restores GSH levels and SOD activity, while it notably reduces MDA levels. Also, cytokines (TNF-α and IL-6) were markedly suppressed by DDS. Significantly, DDS inhibited NLRP3 inflammasome activation, p38 MAPK, and ERK1/2 phosphorylation, as well as VCAM-1 expression, reducing associated effects of inflammation. Conclusions These findings highlight that DDS alleviates CIS-induced liver toxicity by mitigating oxidative injury and inflammation, suggesting it is a promising intervention for chemotherapy-associated liver injury.
Nehad A. Shaer (Mon,) studied this question.