Antibacterial Photodynamic Therapy Using Zinc Phthalocyanine Against Multidrug-resistant Pseudomonas aeruginosa in Burn Infections.

Key Points

• The study aims to evaluate the effectiveness of zinc phthalocyanine in treating multidrug-resistant infections in burn wounds.
• Utilized a nanoemulsion containing zinc phthalocyanine in a burn wound model under in vitro and in vivo conditions.
• Assessed gene expression levels following treatment.
• Evaluated treatment impact on infected rat wounds.
• Treatment restored gene expression to normal levels in infected rat wounds, indicating therapeutic effectiveness.
• NE/ZnPc showed promise as an alternative to conventional antibiotics for MDR bacteria.

Abstract