Does the dose of Sabin Type I oral poliovirus vaccine influence intestinal infection in newborn infants?
Maternal antibody titers and breast feeding reduce the rate of intestinal infection following oral polio vaccination in newborn infants.
The purpose of this investigation was to determine the influence of the dose of Sabin Type I attenuated oral poliovirus vaccine upon the response of newborn infants and to delineate further the factors which alter intestinal infection with this virus. In an earlier study,1fewer newborn infants excreted virus after a single dose of vaccine than did babies 3 months of age. All of the newborns had received 107.5TCD50* in 1 ml. of vaccine virus, a dose which is 100 times that recommended for older children and adults.2Most of the newborns who failed to become infected were born to mothers with antibody titers of 256 or greater. In addition, infants who were breast fed did not appear to become infected so readily as did their bottle-fed peers, particularly when the titer of passive antibody was high. In the previous experiment the dose of 10
Martha L. Lepow (Sun,) studied this question.