Exacerbation of hypertension compromised renal function and structure similarly in normoglycemic obese female ZSF1 rats and hyperglycemic obese male ZSF1 rats.
Does exacerbation of hypertension compromise renal function and structure in female and male obese ZSF1 rats?
In a rat model of HFpEF, exacerbating hypertension worsens renal function and structure similarly in both normoglycemic obese females and hyperglycemic obese males.
Chronic kidney disease coexists with heart failure with a preserved ejection fraction (HFpEF), which is associated with multiple comorbidities and the female sex. We showed that obese, mildly hypertensive female ZSF1 rats, an animal model for HFpEF, simultaneously develop renal disease with diastolic dysfunction. Exacerbation of their hypertension, a comorbidity highly prevalent in HFpEF, compromised renal function and structure similarly in normoglycemic obese female ZSF1 rats and hyperglycemic obese male ZSF1 rats.
Nguyen et al. (Thu,) conducted a other in Chronic kidney disease and heart failure with preserved ejection fraction (HFpEF). Exacerbation of hypertension was evaluated on Renal function and structure. Exacerbation of hypertension compromised renal function and structure similarly in normoglycemic obese female ZSF1 rats and hyperglycemic obese male ZSF1 rats.
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